September 9, 2018

Graphene field-effect transistors (FETs) provide an efficient platform for enabling the label-free detection of DNA molecules. In this study, we used an interfacial polymer brush layer, which is inserted between graphene and SiO2, to enhance the electrical properties o...

May 2, 2017

Retroviral and lentiviral vectors are mostly pseudotyped and often purified and concentrated via ultracentrifugation. In this study, we quantified and compared the stabilities of retroviral [murine leukemia virus (MLV)-based] and lentiviral [human immunodeficiency viru...

August 1, 2016

We showed that physiological properties of a kidney cell type could be greatly altered by means of a custom-designed nanotopography without the use of any biological molecules. The cell is considered as an organic machinery that senses and interprets information from t...

May 5, 2016

Objectives: To develop a method for reliable quantification of viral vectors, which is necessary for determining the optimal dose of vector particles in clinical trials to obtain the desired effects without severe unwanted immune responses. Results: A significant level...

November 3, 2015

In this work, we demonstrate in-situ virus identification based on surface-enhanced Raman scattering (SERS). We hypothe-sized that newly emerging influenza viruses possess surface proteins and lipids that can generate distinctive Raman signals. To test the hypothesis,...

January 1, 2015

Various biological molecules naturally existing in diversified species including fungi, bacteria, and bacteriophage have functionalities for DNA binding and processing. Those biological molecules have been recently actively engineered to be used for customized genome e...

Recombinant adeno-associated virus (rAAV), a non-enveloped virus, is widely used in gene therapy clinical trials because it does not cause human disease, transduces both dividing and non-dividing cells, and mediates stable transgene expression for years in post-mitotic...

October 1, 2012

Neurogenesis in the adult hippocampus involves activation of quiescent neural stem cells (NSCs) to yield transiently amplifying NSCs, progenitors, and, ultimately, neurons that affect learning and memory. This process is tightly controlled by microenvironmental cues, a...

May 1, 2012

The metabolic fate of 3,6-anhydro-L-galactose (L-AHG) is unknown in the global marine carbon cycle. Vibrio sp. strain EJY3 is an agarolytic marine bacterium that can utilize L-AHG as a sole carbon source. To elucidate the metabolic pathways of L-AHG, we have sequenced...

April 30, 2012

Retroviruses have often been used for gene therapy because of their capacity for the long-term expression of transgenes via stable integration into the host genome. However, retroviral integration can also result in the transformation of normal cells into cancer cells,...

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