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Systems and Synthetic Biology Laboratory
Kwang-il Lim's Lab
Department of Chemical and Biological Engineering
Sookmyung Women's University

"SEM Mapping of Sequence-Specific Protein–DNA Interactions on Long DNA Molecules"
Chanyoung Noh, Sangwon Lee, Yoonjung Kang, Taesoo Kim, Taebin Yun, Yoojin Kim, Gyuri Park, Priyannth R Sundharbaabu, Sang-Hee Shim, Kwang-il Lim, Jung Heon Lee, Kyubong Jo.
Nucleic Acids Research 2026
IF=15.0

"Safe and Localized Lentiviral Gene Delivery via Injectable Mesoporous Scaffolds for Potent Antitumor Immunity"
Thanh Loc Nguyen, Yeon-ju Kim, Jihye Im, Dong Kwang Min, Hyunsu Shin, Thuy An Trinh, Ngoc Man Phan, Min-jeong Son, Ji-yeon Shim, Ye-lim Lee, Yujeong Ha, Kwang-il Lim, Jaeyun Kim.
Advanced materials 2026
IF=29.1
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"Rapid and Sensitive Detection of RNA Viruses through Imaging of Marker Molecules Derived from Designed Circular DNA Probes"
Yoon-ha Jang, Taesoo Kim, Su-jin Hong, Se-yeon Kim, Hyeseung Hwang, Siwon Kim, Su-a Kang, Nabin Won, Dogeun Kim, Min Jae Kim, Yong Pil Chong, Seongsoo Jang, Kyubong Jo, Kwang-il Lim.
Small methods 2025
IF=8.7

"Artificial Intelligence Enhanced Analysis of Genomic DNA Visualized with Nanoparticle-Tagged Peptides under Electron Microscopy"
Priyannth Ramasami Sundharbaabu, Junhyuck Chang, Yunchul Kim, Youmin Shim, Byoungsang Lee, Chanyoung Noh, Sujung Heo, Seung Seo Lee, Sang-Hee Shim, Kwang-il Lim, Kyubong Jo, Jung Heon Lee.
Small 2024
IF=12.1

"Scanning Electron Microscopy Imaging of Large DNA Molecules Using a Metal-Free Electro-Stain Composed of DNA-Binding Proteins and Synthetic Polymers"
Chanyoung Noh, Yoonjung Kang, Sujung Heo, Taesoo Kim, Hayeon Kim, Junhyuck Chang, Priyannth Ramasami Sundharbaabu,
Sanghee Shim, Kwang-il Lim, Jung Heon Lee, Kyubong Jo.
Advanced science 2024
IF=14.1

"Probe-Free Identification of RNA Virus Variants with Point Mutations by Surface-Enhanced Raman Spectroscopy"
Su-jin Hong, Eungyeong Park, Yooh-ha Jang, Ji-yeon Shim, Yeonju Park, Sila Jin, Shuang Guo, Yeon-ju Kim, Min-jeong Son, Lei Chen, Kwang-il Lim*, and Young Mee Jung.*
Analytical Chemistry 2022
IF=7.4

"Counting DNA molecules on a microchannel surface for quantitative analysis"
Taesoo Kim, Siwon Kim, Chanyoung Noh, Hyeseung Hwang, Jieun Shin, Nabin Won, Seonghyun Lee, Dogeun Kim, Yoonha Jang, Su-Jin Hong, Jungyul Park, Sung Jae Kim, Seongsoo Jang, Kwang-Il Lim**, Kyubong Jo.*
Talanta 2022
IF=6.1

"Graphene Oxide-Supported Microwell Grids for Preparing Cryo-EM Samples with Controlled Ice Thickness"
Min-Ho Kang, Junsun Park, Sungsu Kang, Sungho Jeon, Minyoung Lee, Ji-Yeon Shim,
Jeeyoung Lee, Tae Jin Jeon, Min Kyung Ahn, Sung Mi Lee, Ohkyung Kwon, Byung Hyo Kim,
Joel R. Meyerson, Min Jae Lee, Kwang-Il Lim,* Soung-Hun Roh,* Won Chul Lee,*
and Jungwon Park.*
Advanced materials 2021
IF=32.1

"Engineering Genetic Systems for Treating Mitochondrial Diseases"
Yoon-ha Jang, Sae Ryun Ahn, Ji-yeon Shim and Kwang-il Lim.*
Pharmaceutics 2021
IF=6.3

"Alteration of gammaretroviral vector integration patterns by insertion of histone and leucine zipper into integrase"
Yeji Yang, Ji-eun Lee, Hye-young Jeong, Ji-yeon Shim, Min-joeng Baek, Min-jeong Son, Yeon-ju Kim, Hohsuk Noh, Kwang-il Lim.*
Biotechnology and Bioengineering 2020
IF=4.5

"Cellular Response of Ventricular-Subventricular Neural Progenitor/Stem Cells to Neonatal Hypoxic-Ischemic Brain Injury and Their Enhanced Neurogenesis"
Jeong Eun Shin, Haejin Lee, Kwangsoo Jung, Miri Kim, Kyujin Hwang, Jungho Han, Joohee Lim, Il-Sun Kim, Kwang-Il Lim* and Kook In Park.*
Yonsei Medical Journal 2020
IF=2.8

"Molecular-Level Interactions between Engineered Materials and Cells"
Yoon-ha Jang, Xuelin Jin, Prabakaran Shankar, Jung Heon Lee,* Kyubong Jo* and Kwang-il Lim.*
International Journal of Molecular Sciences 2019
IF=4.6

"Comparative study on the catalytic activity of Fe-doped ZrO2 nanoparticles without significant toxicity through chemical treatment under various pH conditions"
Hye-in Song, JungA Hong, Hangil Lee* and Kwang-il Lim.*
Scientific Reports 2019
IF=4.0

"Attomolar detection of virus by liquid coplanar-gate graphene transistor on plastic"
Jin Woo Kim, Seunghyun Kim, Yoon-ha Jang, Kwang-il Lim* and Wi Hyoung Lee.*
Nanotechnology 2019
IF=3.6

"Nanotopography-based engineering of retroviral DNA integration patterns"
Yoon-ha Jang, Yi-seul Park, Jung-soo Nam, Yeji Yang, Ji-eun Lee, Kwang-hee Lee, Minho Kang, Alex Chialastri, Hohsuk Noh, Jungwon Park, Jin Seok Lee* and Kwang-il Lim.*
Nanoscale 2019
IF=6.9

"Identification of Newly Emerging Influenza Viruses by Detecting the Virally Infected Cells Based on Surface Enhanced Raman Spectroscopy and Principal Component Analysis"
Jae-young Lim, Jung-soo Nam, Hyunku Shin, Jaena Park, Hye-in Song, Minsung Kang, Kwang-il Lim,* and Yeonho Choi.*
Analytical Chemistry 2019
IF=6.8

"Shifting Retroviral Vector Integrations Away from Transcriptional Start Sites via DNA-Binding Protein Domain Insertion into Integrase"
Jung-soo Nam, Ji-eun Lee, Kwang-hee Lee, Yeji Yang, Soo-hyun Kim, Gyu-un Bae, Hohsuk Noh and Kwang-il Lim.*
Molecular Therapy-Methods & Clinical Development 2018
IF=4.9

"Single-molecule DNA visualization using
AT-specific red and non-specific green DNA-binding fluorescent proteins"
Jihyun Park, Seonghyun Lee, Nabin Won, Eunji Shin, Soo-Hyun Kim, Min-Young Chun, Jungyeun Gu, Gun-Young Jung, Kwang-Il Lim* and Kyubong Jo.*
Analyst 2018
IF=4.0

"Interfacial Polymer Brush Layer for DNA Sensors Based on Graphene Transistors"
Gwang Mo Ku, Jin Woo Kim, Yoon-ha Jang, Seunghyun Kim, Kwang-il Lim, and Wi Hyoung Lee.*
Fibers and Polymers 2018
IF=1.4

"Recent Advances in Mitochondria-Targeted Gene Delivery"
Yoon-ha Jang and Kwang-il Lim.*
Molecules 2018
IF=3.1

"Liquid coplanar-gate organic/graphene hybrid electronics for label-free detection of single and double-stranded DNA molecules"
Jin Woo Kima, Yoon-ha Jang, Gwang Mo Kua, Seunghyun Kim, Eunho Lee, Kilwon Cho, Kwang-il Lim,* Wi Hyoung Lee.*
Organic Electronics 2018
IF=3.5

"Stability of Retroviral Vectors Against Ultracentrifugation Is Determined by the Viral Internal Core and Envelope Proteins Used for Pseudotyping"
Soo-hyun Kim, and Kwang-il Lim.*
Molecules and Cells 2017
IF=3.1

"Filopodia Formation and Proliferation of Mammalian Cells Are Increased on Closely Packed Silica Nanobeads"
Yoon-ha Jang, Seo Young Yoon, Young-hoo Cho, Dahyun Lee, Jin Seok Lee* and Kwang-il Lim.*
Bulletin of the Korean Chemical Society 2016
IF=0.6

"Reliable RT-qPCR-based titration of retroviral and lentiviral vectors via quantification of residual vector plasmid DNA in samples"
Yoon-ha Jang, Hye-in Song, Yeji Yang, Kwang-il Lim.
Biotechnology Letters 2016
IF=1.7

"Identification of Newly Emerging Influenza Viruses by Surface- Enhanced Raman Spectroscopy"
Jae-young Lim, Jung-soo Nam, Se-eun Yang, Hyunku Shin, Yoon-ha Jang, Gyu-Un Bae, Taewook Kang, Kwang-il Lim, and Yeonho Choi.
Analytical Chemistry 2015
IF=5.9

"Enhanced cellular secretion of AAV2 by expression of foreign viral envelope proteins"
Melissa Kottermana, James T. Koerbera, Jung-soo Nam, Young-hoo Cho, Seung-hyun Kim, Jae-hyung Jang, Kwang-il Lim.
Biochemical Engineering Journal 2014
IF=2.5

"Recent advances in developing molecular tools for targeted genome engineering of mammalian cells"
Kwang-il Lim.
BMB Reports 2014
IF=2.6

"Astrocytes regulate adult hippocampal neurogenesis through ephrin-B signaling"
Randolph S. Ashton, Anthony Conway, Chinmay Pangarkar, Jamie Bergen, Kwang-Il Lim, Priya Shah, Mina Bissell, and David V. Schaffer.
Nature Neuroscience 2013
IF=15.0

"Genome Sequence of Vibrio sp. Strain EJY3, an Agarolytic Marine Bacterium Metabolizing 3,6-Anhydro-L-Galactose as a Sole Carbon Source"
Hanseong Roh, Eun Ju Yun, Saeyoung Lee, Hyeok-Jin Ko, Sujin Kim, Byung-Yong Kim, Heesang Song, Kwang-il Lim, Kyoung Heon Kim, and In-Geol Choi.
Journal of Bacteriology 2012
IF=3.2

"Retroviral integration profiles: their determinants and implications for gene therapy"
Kwang-il Lim.
BMB Reports 2012
IF=1.6

"Retroviral Infection of hES Cells Produces Random-like Integration Patterns"
Kwang-il Lim.
Molecules and Cells 2012
IF=2.2

"Resistive switching memory properties of layer-by-layer assembled enzyme multilayers"
Hyunhee Baek, Chanwoo Lee, Kwang-il Lim and Jinhan Cho.
Nanotechnology 2011
IF=4.0

"Specific insertions of zinc finger domains into Gag-Pol yield engineered retroviral vectors with selective integration properties"
Kwang-il Lim, Ryan Klimczak, Julie H. Yu, and David V. Schaffer.
PNAS U.S.A. 2010
IF=9.8

"Combinatorial Latency Reactivation for HIV-1 Subtypes and Variants"
John C. Burnett, Kwang-il Lim, Arash Calafi, John J. Rossi, David V. Schaffer and Adam P. Arkin.
Journal of Virology 2010
IF=5.2

"Computational Fitness Landscape for All Gene-Order Permutations of an RNA Virus"
Kwang-il Lim, John Yin.
PLoS Computational Biology 2009
IF=5.8

"Molecular Engineering of Viral Gene Delivery Vehicles"
David V. Schaffer, James T. Koerber and Kwang-il Lim.
Annual Review of Biomedical Engineering 2009
IF=11.2

"Library Selection Approaches to Engineering Enhanced Retroviral and Lentiviral Vectors"
Kwang-il Lim and David V. Schaffer.
Combinatorial Chemistry & High Throughput Screening 2008
IF=1.7

"Library Selection and Directed Evolution Approaches to Engineering Targeted Viral Vectors"
Jae-Hyung Jang, Kwang-il Lim, David V. Schaffer.
Biotechnology and Bioengineering 2007
IF=3.0

"Model-Based Design of Growth-Attenuated Viruses"
Kwang-il Lim, Tobias Lang, Vy Lam, John Yin.
PLoS Computational Biology 2006
IF=4.9

"Dynamic Tradeoffs in the Raft-Mediated Entry of Human Immunodeficiency Virus Type 1 Into Cells"
Kwang-il Lim, John Yin.
Biotechnology and Bioengineering 2005
IF=2.5

"Localization of Receptors in Lipid Rafts Can Inhibit Signal Transduction"
Kwang-il Lim, John Yin.
Biotechnology and Bioengineering 2005
IF=2.5

"Engineering Virus Growth by Gene-order Permutation"
Kwang-il Lim, Vy Lam, Tobias Lang and John Yin.
PLoS Computational Biology 2005
IF=4.9

"Effects of lipid rafts on dynamics of retroviral entry and trafficking: Quantitative analysis"
Kwang-il Lim, Shakti Narayan, John A.T. Young, John Yin.
Biotechnology and Bioengineering 2004
IF=2.2
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