May 1, 2005

Processes of cell survival, division, differentiation, and death are guided by the binding of signal molecules to receptors, which activates intracellular signaling networks and ultimately elicits genetic, biochemical, or biomechanical responses within the cell. While...

January 1, 2005

How does the growth of an organism depend on the linear arrangement of its genes? For viruses, changes in gene order may inhibit or enhance growth, advancing their use as live attenuated vaccines, gene-therapy vectors or anti-tumor therapeutics. We have developed a kin...

April 1, 2004

The association of cell surface receptors with sterol-sphingolipid-enriched microdomains of the plasma membrane, so-called lipid rafts, may affect the receptor-mediated entry and trafficking dynamics of viruses. A model retrovirus, subgroup A avian sarcoma and leukosis...

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